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Find cheap one-way flights from San Francisco to Santo Domingo starting at US$191.

Book one-way or return flights from San Francisco to Santo Domingo from as little as US$191. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from San Francisco to Santo Domingo?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from San Francisco to Santo Domingo

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Frontier Airlines
From US$171
Copa Airlines
From US$193
Jetblue Airways
From US$210
Aeromexico
From US$231
Alaska Airlines
From US$243
American Airlines
From US$254
Delta Air Lines
From US$260
United Airlines
From US$263
Southwest Airlines
From US$296
Sun Country Airlines
From US$333
ANA airlines

Find more flights and airlines

Find cheap flights from San Francisco to Santo Domingo by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from San Francisco to Santo Domingo.

  • Cheapest
    Frontier Airlines
    SFO
    00:21
    22h 51m
    2 transfer
    SDQ
    02:12
    San Francisco International Airport - Las Américas International Airport
    Wed, Mar 20Frontier Airlines
    US$171
  • Frontier Airlines
    SFO
    00:21
    22h 51m
    2 transfer
    SDQ
    02:12
    San Francisco International Airport - Las Américas International Airport
    Wed, Mar 20Frontier Airlines
    US$171
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from San Francisco (SFO) to Santo Domingo (SDQ) the cheapest?

    Airlines adjust prices for flights from San Francisco to Santo Domingo based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from San Francisco (SFO) to Santo Domingo (SDQ) cost?

    According to Trip.com's data, the lowest price is around $770.
  • What is the transportation method from the main airport to downtown in Santo Domingo?

    • The distance from Las Américas International Airport to downtown is about 33km. It takes about 50 minutes by taxi.
    • The distance from La Isabela International Airport to downtown is about 8km. It takes about 20 minutes by taxi.

San Francisco to Santo Domingo Flight Information

Cheapest nonstop flight price

$192

Off-season for travel

October

Peak season for travel

June