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Find cheap one-way flights from Madrid to Santa Cruz starting at US$330.

Book one-way or return flights from Madrid to Santa Cruz from as little as US$330. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Madrid to Santa Cruz?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Madrid to Santa Cruz

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Air Europa
From US$330
Boliviana De Aviación
From US$361
LATAM Airlines
From US$375
Iberia
From US$382
Vueling Airlines
From US$394
Avianca
From US$507
TAP Air Portugal
From US$509
Aerolineas Argentinas
From US$515
Lufthansa
From US$565
Swiss Airlines
From US$577
ANA airlines

Find more flights and airlines

Find cheap flights from Madrid to Santa Cruz by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Madrid to Santa Cruz.

  • Cheapest
    Air Europa
    MAD
    23:35
    11h 5m
    Direct
    VVI
    04:40
    Madrid Barajas Airport - Viru Viru International Airport
    Mon, May 6Air Europa
    US$330
  • Accesrail And Partner Railways
    07:30
    24h 30m
    2 transfer
    VVI
    02:00
    undefined - Viru Viru International Airport
    Sun, Jun 2Accesrail And Partner Railways
    US$692
  • Accesrail And Partner Railways
    07:30
    24h 30m
    2 transfer
    VVI
    02:00
    undefined - Viru Viru International Airport
    Sun, Jun 2Accesrail And Partner Railways
    US$692
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Madrid (MAD) to Santa Cruz (SRZ) the cheapest?

    Airlines adjust prices for flights from Madrid to Santa Cruz based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Madrid (MAD) to Santa Cruz (SRZ) cost?

    According to Trip.com's data, the lowest price is around $1,177.
  • How long does it take to fly from Madrid (MAD) to Santa Cruz (SRZ) and what is the distance?

    It takes around 11 hours 1 minute to fly from Madrid (MAD) to Santa Cruz (SRZ).
  • What is the transportation method from the main airport to downtown in Santa Cruz?

    • The distance from Viru Viru International Airport to downtown is about 17km. It takes about 30 minutes by taxi.
  • What are the most popular airlines that fly from Madrid (MAD) to Santa Cruz (SRZ)?

    Airlines with flights from Madrid (MAD) to Santa Cruz (SRZ): Iberia, Boliviana De Aviación and Air Europa.

Madrid to Santa Cruz Flight Information

Cheapest nonstop flight price

$330

Cheapest round-trip ticket price

$761

Off-season for travel

December

Peak season for travel

October